ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) (Synonyms: MEHFRWGK-OH) |
| رقم الكتالوجGC31530 |
ACTH 4-11 (هرمون قشر الكظر (4-11) ، الإنسان) ، وهو جزء من هرمون قشر الكظر ، يمتلك α ضعيفًا ؛ -الهرمون المنشط للخلايا الصباغية (α ؛ -MSH) فقط بجرعات عالية (100 و 1000 نانومتر).
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Cas No.: 67224-41-3
Sample solution is provided at 25 µL, 10mM.
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ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does. α-MSH induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. ACTH (4-11) loses almost all activity for the binding to melanocortin receptor 1 (MC1R)[1].
[1]. Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40.
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