Adenosine receptor antagonist 2 |
| رقم الكتالوجGC65901 |
مضاد مستقبلات الأدينوزين 2 هو مضاد لمستقبلات الأدينوزين A2a / A2b النشط عن طريق الفم مع IC50s من 1 نانومتر و 3 نانومتر ، على التوالي. مضاد مستقبلات الأدينوزين 2 له نشاط مضاد للورم.
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Cas No.: 2703054-47-9
Sample solution is provided at 25 µL, 10mM.
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Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].
Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1].
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min.kg and an AUC of 2252 h.ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].
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