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ADS032

رقم الكتالوجGC71405 Copy One-Click Copy Product Info

ADS032 هو مثبط مزدوج ل NLRP1 و NLRP3 التي يمكن أن تمنع بسرعة، عكس عكس وثبات تشكيل الالتهاب.

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ADS032 التركيب الكيميائي

Cas No.: 2757333-37-0

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
119٫00
متوفر
5 mg
108٫00
متوفر
10 mg
185٫00
متوفر
25 mg
369٫00
متوفر
50 mg
630٫00
متوفر
100 mg
1008٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of ADS032

ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin -induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively.

Chemical Properties of ADS032

Cas No. 2757333-37-0 SDF
Formula C22H29NO4S M.Wt 403.53
الذوبان DMSO : 100 mg/mL (247.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)Ethanol : 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of ADS032

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4781 mL 12.3907 mL 24.7813 mL
5 mM 495.6 μL 2.4781 mL 4.9563 mL
10 mM 247.8 μL 1.2391 mL 2.4781 mL
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In vivo Formulation Calculator (Clear solution) of ADS032

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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مراجعات

Review for ADS032

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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