Aleplasinin (Synonyms: PAZ-417) |
| رقم الكتالوجGC65281 |
أليبلاسينين هو مثبط فعال عن طريق الفم ، قوي ، مخترق من قبل BBB وانتقائي SERPINE1 (PAI-1 ، مثبط منشط البلازمينوجين -1)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 481629-87-2
Sample solution is provided at 25 µL, 10mM.
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Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].
[1]. Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4.
[2]. Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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