Arachidonoyl amide (Synonyms: Arachidonamide,Arachidonic Acid amide) |
رقم الكتالوجGC16826
One-Click Copy Product Info
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CB1 receptor agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 85146-53-8
Sample solution is provided at 25 µL, 10mM.
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Arachidonoyl amide is a CB1 receptor agonist [1]. The cannabinoid receptor type 1, abbreviated as CB1, is a G protein-coupled cannabinoid receptor expressed primarily in the central and peripheral nervous system. CB1 receptor has been implicated in maintaining the homeostasis in health and disease. Overexpression of CB1 receptor has been found in human hepatocellular carcinoma tumor samples and other human prostate cancer cells [2].
Arachidonoyl amide is an analog of anandamide (AEA) that lacks the hydroxyethyl moiety. It was hydrolyzed by FAAH more effectively than AEA but exhibited significantly weaker binding to the human CB1 receptor with a Ki of 9.6 μM [1]. Arachidonoyl amide exhibited similar binding and translocation into cells via the AEA transporter compared to AEA. Arachidonoyl amide inhibited [3H]-AEA uptake into human astrocytoma cells with an IC50 of 9 μM [3].
References:
[1] Felder C C, Briley E M, Axelrod J, et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction[J]. Proceedings of the National Academy of Sciences, 1993, 90(16): 7656-7660.
[2] Pertwee R G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin[J]. British journal of pharmacology, 2008, 153(2): 199-215.
[3] Piomelli, D. ,Beltramo, M.,Glasnapp, S., et al. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America 96, 5802-5807 (1999).
| Cas No. | 85146-53-8 | SDF | |
| المرادفات | Arachidonamide,Arachidonic Acid amide | ||
| Chemical Name | 5Z,8Z,11Z,14Z-eicosatetraenamide | ||
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)N | ||
| Formula | C20H33NO | M.Wt | 303.5 |
| الذوبان | ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2949 mL | 16.4745 mL | 32.9489 mL |
| 5 mM | 659 μL | 3.2949 mL | 6.5898 mL |
| 10 mM | 329.5 μL | 1.6474 mL | 3.2949 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)