ATB-337 (Synonyms: ACS 15,S-Diclofenac) |
| رقم الكتالوجGC12537 |
ATB-337 هو جزيء هجين لمتبرع H2S وديكلوفيناك NSAID.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 912758-00-0
Sample solution is provided at 25 µL, 10mM.
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ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac [1].
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].
Oral administration of ATB-337 did not produce any hemorrhagic erosions. Oral administration of an equimolar dose of ATB-337 produced > 90% less small intestinal damage and showed no significant effect on the hematocrit. In rats, administration of ATB-337 (50 μmol/kg) showed no significant effect on leukocyte adherence. Oral administration of ATB-337 significantly increased plasma levels of H2S by > 40%. In a rat air pouch model, ATB-337 (1 μmol/kg) suppressed COX-2 activity. In the rat, ATB-337 inhibited thromboxane synthesis. ATB-337 suppressed arachidonic acid–induced human platelet aggregation. Pretreatment with ATB-337 (10 μmol/kg) reduced paw swelling. ATB-337 generated ～12nmol/min of H2S when it was incubated in buffer.
References:
[1] Wallace J L, Caliendo G, Santagada V, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide–releasing diclofenac derivative in the rat[J]. Gastroenterology, 2007, 132(1): 261-271.
[2] Wallace J L. Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[J]. Antioxidants & redox signaling, 2010, 12(9): 1125-1133.
| Cas No. | 912758-00-0 | SDF | |
| المرادفات | ACS 15,S-Diclofenac | ||
| Chemical Name | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester | ||
| Canonical SMILES | O=C(Oc1ccc(cc1)c1ssc(=S)c1)Cc1ccccc1Nc1c(Cl)cccc1Cl | ||
| Formula | C23H15NCl2O2S3 | M.Wt | 504.5 |
| الذوبان | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.9822 mL | 9.9108 mL | 19.8216 mL |
| 5 mM | 0.3964 mL | 1.9822 mL | 3.9643 mL |
| 10 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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