AZD 3147 |
| رقم الكتالوجGC18566 |
AZD 3147 هو مثبط مزدوج انتقائي فعال عن طريق الفم لـ mTORC1 و mTORC2 بقيمة IC50 تبلغ 1.5 نانومتر. AZD 3147 له أيضًا تأثير انتقائي على PI3K.
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Cas No.: 1101810-02-9
Sample solution is provided at 25 µL, 10mM.
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AZD 3147 is an orally bioavailable dual inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 (IC50s = 40.7 and 5.75 nM, respectively, in MDA-MB-468 cells).[1] It is selective for mTOR over PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ (IC50s = 1.51, 912, 5,495, 9,333, and 6,310 nM, respectively, in enzyme assays).
Reference:
[1]. Pike, K.G., Morris, J., Ruston, L., et al. Discovery of AZD3147: A potent, selective dual inhibitor of mTORC1 and mTORC2. J. Med. Chem. 58(5), 2326-2349 (2015).AZD 3147
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