AZD9898 |
| رقم الكتالوجGC64919 |
AZD9898 هو مثبط نشاط leukotriene-C4 synthetase (LTC4S ، الجلوتاثيون S-ترانسفيراز II) عن طريق الفم ، مع IC50 من 0.28 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2042347-69-1
Sample solution is provided at 25 µL, 10mM.
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AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].
AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1].
[1]. Munck Af RosenschÖld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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