Azoxystrobin (Synonyms: ICI-A 5504) |
رقم الكتالوجGC46904
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أزوكسيستروبين مبيد فطري واسع الطيف بيتا-ميثوكسي أكريلات
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 131860-33-8
Sample solution is provided at 25 µL, 10mM.
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Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide (LC95s = <1 mg/L for ascomycete, basidiomycete, deuteromycete, and oomycete plant pathogens).1 It inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer.2 Azoxystrobin is cytotoxic to MDA-kb2 cells with an EC20 value of 2.9 µM but has no antiandrogenic activity.3 It disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of reactive oxygen species (ROS) in zebrafish larva when used at doses ranging from 0.1 to 100 µg/L.4 Azoxystrobin inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours) and induces apoptosis in a time- and dose-dependent manner.5 In a KYSE-150 nude mouse xenograft model, azoxystrobin reduces tumor growth when administered at a dose of 40 mg/kg per day.
1.Godwin, J.R., Anthony, V.M., Clough, J.M., et al.ICI A5504: A novel, broad spectrum, systemic β-methoxyacrylate fungicideBrit. Crop Prot. Conf. - Pests and Dis., Proc.1435-442(1992) 2.Wiggins, T.E., and Jager, B.J.Mode of action of the new methoxyacrylate antifungal agent ICIA5504Biochem. Soc. Trans.22(1)68S(1994) 3.Orton, F., Rosivatz, E., Scholze, M., et al.Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogensEnviron. Health Perspect.119(6)794-800(2011) 4.Jiang, J., Shi, Y., Yu, R., et al.Biological response of zebrafish after short-term exposure to azoxystrobinChemosphere20256-64(2018) 5.Shi, X.K., Bian, X.B., Huang, T., et al.Azoxystrobin induces apoptosis of human esophageal squamous cell carcinoma KYSE-150 cells through triggering of the mitochondrial pathwayFront. Pharmacol.8277(2017)
| Cas No. | 131860-33-8 | SDF | |
| المرادفات | ICI-A 5504 | ||
| Canonical SMILES | CO/C=C(C(OC)=O)\C(C=CC=C1)=C1OC2=NC=NC(OC3=C(C#N)C=CC=C3)=C2 | ||
| Formula | C22H17N3O5 | M.Wt | 403.4 |
| الذوبان | DMSO : 100 mg/mL (247.90 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4789 mL | 12.3946 mL | 24.7893 mL |
| 5 mM | 495.8 μL | 2.4789 mL | 4.9579 mL |
| 10 mM | 247.9 μL | 1.2395 mL | 2.4789 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)