BM212 |
| رقم الكتالوجGC18217 |
BM212 هو مثبط قوي لبروتين غشاء Mycobacterial Large 3 (MmpL3)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 146204-42-4
Sample solution is provided at 25 µL, 10mM.
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BM212 is an antimycobacterial compound. It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains (MICs = 0.7-1.5 μg/ml), including strains resistant to ethambutol , isoniazid , rifampicin , and rifabutin. BM212 also inhibits the growth of M. fortuitum, M. smegmatis, M. kansasii, and M. avium strains (MICs = 3.1-12.5, 3.1-25, 3.1-6.2, and 0.4-3.1 μg/ml, respectively). It inhibits replication of intracellular M. tuberculosis in infected U937 macrophages in a dose-dependent manner at concentrations ranging from 0.5-10 μg/ml. Some M. smegmatis, M. bovis BCG, and M. tuberculosis H37Rv mutant strains carry mutations in the mycobacterium membrane protein large 3 (mmpL3) gene and are resistant to BM212, indicating mmpL3 is likely a cellular target of BM212.
Review for BM212
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
Review for BM212
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