BMS-1166 (PD-1/PD-L1-IN1) |
| رقم الكتالوجGC31753 |
BMS-1166 (PD-1 / PD-L1-IN1) هو مثبط قوي لنقطة التفتيش المناعية PD-1 / PD-L1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1818314-88-3
Sample solution is provided at 25 µL, 10mM.
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BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].
[1]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. [2]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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