BMSpep-57 hydrochloride |
| رقم الكتالوجGC62682 |
هيدروكلوريد BMSpep-57 هو مثبط قوي وتنافسي للببتيد كبير الحلقات لتفاعل PD-1 / PD-L1 مع IC50 من 7.68 نانومتريرتبط هيدروكلوريد BMSpep-57 بـ PD-L1 بـ Kds من 19 نانومتر و 19.88 نانومتر في فحوصات MST و SPR ، على التواليهيدروكلوريد BMSpep-57 يسهل وظيفة الخلايا التائية من خلال تجعيد إنتاج IL-2 في PBMCs
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs[1].
In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in SEB-stimulated peripheral blood mononuclear cells[1].BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].
[1]. Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9(1):12392.
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