BVDV-IN-1 |
| رقم الكتالوجGC62136 |
BVDV-IN-1 هو مثبط غير نوكليوزيد (NNI) لفيروس الإسهال الفيروسي البقري (BVDV) ، مع EC50 من 1.8 ميكرومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 345651-04-9
Sample solution is provided at 25 µL, 10mM.
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BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1].
BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp)[1].BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro[1].
[1]. Gabriela A FernÁndez, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.
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