c-di-AMP |
| رقم الكتالوجGC13643 |
c-di-AMP (Cyclic diadenylate) هو ناهض STING ، والذي يرتبط ببروتين الغشاء STING وبالتالي تنشيط مسار إشارات TBK3-IRF3 ، مما يؤدي لاحقًا إلى إنتاج النوع I IFN و TNF
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Cas No.: 54447-84-6
Sample solution is provided at 25 µL, 10mM.
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C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP serves as a second messenger in bacteria, primarily regulating cell growth, survival, and virulence in Gram-positive bacteria, and also modulates the host immune response. As an effective mucosal adjuvant, c-di-AMP stimulates both humoral and cellular responses[1-5]. C-di-AMP have been utilized as vaccine adjuvants for influenza and hepatitis C.Citation[6].
Combination of c-di-AMP(5 ug/ml;48h) with radiation promotes the secretion of type I IFN and ISG levels in BMDCs[7].
C-di-AMP(25ug;i.p;3 times) can synergistically enhance the antitumor effects of Radiotherapy (RT)-associated dsDNA by promoting IFN-β production and CD8+ cytolytic T cell activation in a cGAS- and STING-dependent manner in mice[7].
References:
[1]. Jenal U, Reinders A, et,al.Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017 May;15(5):271-284. doi: 10.1038/nrmicro.2016.190. Epub 2017 Feb 6. PMID: 28163311.
[2]. Fahmi T, Port GC, et,al.c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulence of Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8):197. doi: 10.3390/genes8080197. PMID: 28783096; PMCID: PMC5575661.
[3]. Ning H, Wang L, et,al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. doi: 10.3389/fimmu.2019.01519. PMID: 31333655; PMCID: PMC6618344.
[4]. Ebensen T, Delandre S, et,al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. doi: 10.3389/fcimb.2019.00031. PMID: 30838180; PMCID: PMC6390046.
[5]. Sanchez MV, Ebensen T, et,al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824. doi: 10.1371/journal.pone.0104824. PMID: 25140692; PMCID: PMC4139298.
[6]. Yin W, Cai X, et,al. A decade of research on the second messenger c-di-AMP. FEMS Microbiol Rev. 2020 Nov 24;44(6):701-724. doi: 10.1093/femsre/fuaa019. PMID: 32472931; PMCID: PMC7850090.
[7]. Li Z, Zhang Y, et,al. Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling. Gut Microbes. 2022 Jan-Dec;14(1):2119055. doi: 10.1080/19490976.2022.2119055. PMID: 36093568; PMCID: PMC9467592.
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