Capromorelin Tartrate (Synonyms: CP 424,391-18, RQ-00000005) |
رقم الكتالوجGC19087 |
Capromorelin Tartrate هو ناهض لمستقبل إفراز هرمون النمو الفعال عن طريق الفم (GHSR) ، مع Ki من 7 نانومتر لـ hGHS-R1a
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Cas No.: 193273-69-7
Sample solution is provided at 25 µL, 10mM.
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM[2].
Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv[2].
References:
[1]. Zollers B, et al. Capromorelin oral solution (ENTYCE®) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study. BMC Vet Res. 2017 Jan 5;13(1):10.
[2]. Carpino PA, et al. Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorg Med Chem. 2003 Feb 20;11(4):581-90.
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