Carbazeran |
| رقم الكتالوجGC41449 |
كاربازيران ، مثبط قوي للفوسفوديستيراز ، هو ركيزة ألدهيد أوكسيديز
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70724-25-3
Sample solution is provided at 25 µL, 10mM.
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Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively. Carbazeran is also a substrate for the enzyme aldehyde oxidase (AOX1), which is involved in the metabolism of xenobiotics.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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