Prolyl Endopeptidase Inhibitor 1 (Synonyms: Boc-Pro-prolinal; (Boc)-Prolyl-prolinal; BPP) |
| رقم الكتالوجGC38838 |
مثبط Prolyl Endopeptidase 1 (Boc-Pro-prolinal) هو مثبط قوي للإندوبيبتيداز (PEP ؛ PE) ، بقيمة كي تبلغ 15 نانومتر
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Cas No.: 86925-97-5
Sample solution is provided at 25 µL, 10mM.
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Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a Ki value of nM order, while the Ki value for the microbial enzyme is only of microM order (Ki=3.2 μM for Flavobacterium)[1].
[1]. Yoshimoto T, et al. Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn. 1987 Dec;10(12):730-5. [2]. Yoshimoto T, et al. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium. J Biochem. 1985 Oct;98(4):975-9.
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