KG 5 |
| رقم الكتالوجGC50133 |
KG 5 هو مثبط خيفي ثنائي نشط عن طريق الفم PDGFRβ و B-Raf. KG 5 يمنع أيضًا Flt3 و KIT و c-Raf. رياض الأطفال 5 لديه أنشطة مضادة للسرطان ومضادة لتولد الأوعية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 877874-85-6
Sample solution is provided at 25 µL, 10mM.
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PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.
Murphy et al (2010) Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc.Natl.Acad.Sci.U.S.A. 107 4299 PMID:20154271 |Mielgo et al (2011) A MEK-independent role for CRAF in mitosis and tumor progression. Nat.Med. 17 PMID:22081024
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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