AMG8379 |
| رقم الكتالوجGC39696 |
AMG8379 هو مضاد سلفوناميد قوي ، فعال عن طريق الفم وانتقائي لقناة الصوديوم ذات الجهد الكهربائي NaV1.7 ، مع IC50s 8.5 و 18.6 نانومتر لـ hNaV1.7 و mNaV1.7 ، على التوالي
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Cas No.: 1642112-31-9
Sample solution is provided at 25 µL, 10mM.
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AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1].
[1]. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.
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