BIO-11006 acetate |
| رقم الكتالوجGC60644 |
أسيتات BIO-11006 ، وهو نظير لببتيد MANS ، هو مثبط MARCKS (ركيزة C كيناز غنية بالألانين)
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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BIO-11006 acetate, an analog of the MANS peptide, is a MARCKS (myristoylated alanine-rich C kinase substrate) inhibitor[1].
Inhaled, aerosolized BIO-11006 acetate attenuates LPS-induced neutrophil influx into the lung, activation of NF-κB, and expression of the proinflammatory cytokines, KC and TNF-α, and thus reverses the development of lung injury in mice instilled intratracheally with LPS[1].
[1]. Yin Q, et al. An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016 Nov;55(5):617-622.
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