Busulfan-d8 (Synonyms: Busulphan-d8, Mielosan-d8, Milecitan-d8, Myeloleukon-d8, Mylecytan-d8, Myleran-d8)

Name: Busulfan-d8
Brand: GlpBio
SKU: GC46962
Availability: InStock
Rating: 5 (10 reviews)

رقم الكتالوجGC46962

Busulfan-D8 هو الديوتيريوم المسمى بوسلفان. بوسولفان عبارة عن سلفونات ألكيل تعمل كعامل مؤلكل مضاد للأورام. يشكل Busulfan روابط متشابكة داخلية ومتشابكة على الحمض النووي. في الثدييات ، يسبب Busulfan انخفاضًا عميقًا وطويل الأمد في توليد أسلاف مكونة للدم دون التأثير بشكل كبير على مستويات الخلايا الليمفاوية أو استجابات الأجسام المضادة الخلطية.

Products are for research use only. Not for human use. We do not sell to patients.

Busulfan-d8 التركيب الكيميائي

Cas No.: 116653-28-2

الحجم

السعر

المخزون

الكميّة

1 mg	81٫00	متوفر
5 mg	387٫00	متوفر

Tel：(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.

منتجات GlpBio المذكورة في الأوراق ذات السمعة الطيبة

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >98.00%

Busulfan-d₈ is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.¹ It forms both intra- and interstrand crosslinks on DNA.^2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.⁴

1.Appelbaum, F.R.Optimizing the conditioning regimen for acute myeloid leukemiaBest Pract.Res.Clin.Haematol.22(4)543-550(2009) 2.Iwamoto, T., Hiraku, Y., Oikawa, S., et al.DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effectCancer Science95454-458(2004) 3.Ponti, M., Souhami, R.L., Fox, B.W., et al.DNA interstrand crosslinking and sequence selectivity of dimethanesulphonatesBritish Journal of Cancer63(5)743-747(1991) 4.Copelan, E.A., and Deeg, H.J.Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiationBlood80(7)1648-1658(1992)

Cas No.	116653-28-2	SDF
المرادفات	Busulphan-d8, Mielosan-d8, Milecitan-d8, Myeloleukon-d8, Mylecytan-d8, Myleran-d8
Canonical SMILES	CS(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OS(C)(=O)=O)(=O)=O
Formula	C6H6D8O6S2	M.Wt	254.3
الذوبان	DMF: 16.7 mg/ml,DMSO: 16.7 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml	Storage	Store at -20°C,protect from light
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	3.9324 mL	19.6618 mL	39.3236 mL
	5 mM	0.7865 mL	3.9324 mL	7.8647 mL
	10 mM	0.3932 mL	1.9662 mL	3.9324 mL

حاسبة المولارية
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احسب

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

مراجعات

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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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Busulfan-d8 (Synonyms: Busulphan-d8, Mielosan-d8, Milecitan-d8, Myeloleukon-d8, Mylecytan-d8, Myleran-d8)

مراجعات العميل

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