Palmitelaidic Acid-d13 (Synonyms: C16:1(9E)-d13, 9-trans-Hexadecenoic Acid-d13)

Palmitelaidic acid-d₁₃ is intended for use as an internal standard for the quantification of palmitelaidic acid by GC- or LC-MS. Palmitelaidic acid is a trans isomer of palmitoleic acid and dietary fatty acid that has been found in dairy fat products and various partially hydrogenated oils.^1,2 It decreases nitric oxide (NO) production and levels of soluble E-selectin in isolated human aortic endothelial cells (HAECs) when used at a concentration of 20 µM.¹ Palmitelaidic acid (49 µM) inhibits Sendai virus-induced hemolysis of isolated human erythrocytes.³ Increased serum levels of palmitelaidic acid are associated with higher levels of LDL, but lower levels of triglycerides, fasting insulin, blood pressure, and incidence of diabetes.²

1.Livingstone, K.M., Givens, D.I., Jackson, K.G., et al.Comparative effect of dairy fatty acids on cell adhesion molecules, nitric oxide and relative gene expression in healthy and diabetic human aortic endothelial cellsAtherosclerosis234(1)65-72(2014) 2.Mozaffarian, D., de Oliveira Otto, M.C., Lemaitre, R.N., et al.trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: The multi-ethnic study of atherosclerosis (MESA)Am. J. Clin. Nutr.97(4)854-861(2013) 3.MacDonald, R.C., Ore, V.D., and MacDonald, R.I.Inhibition of sendai virus-induced hemolysis by long chain fatty acidsVirology134(1)103-117(1984)