PRGL493 |
| رقم الكتالوجGC47973 |
PRGL493 هو مثبط قوي وانتقائي طويل السلسلة من إنزيم acyl-CoA synthetase 4 (ACSL4)يمنع PRGL493 تكاثر الخلايا ونمو الورم في كل من النماذج الخلوية والحيوانية للثدي والبروستاتايستخدم PRGL493 لأبحاث السرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2479378-45-3
Sample solution is provided at 25 µL, 10mM.
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PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1 It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020)
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