BX-320 |
رقم الكتالوجGC48433 |
BX-320 هو مثبط PDK1 انتقائي تنافسي لـ ATP وحامض شفوي ومباشر مع IC50 من 30 نانومتر في تنسيق فحص كيناز مباشريستحث BX-320 أيضًا موت الخلايا المبرمجتأثير مضاد للسرطان
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Cas No.: 702676-93-5
Sample solution is provided at 25 µL, 10mM.
BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC50 = 30 nM).1 It is selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all). BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 µM). It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 µM). BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.
1.Feldman, R.I., Wu, J.M., Polokoff, M.A., et al.Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1J. Biol. Chem.280(20)19867-19874(2005)
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