Ofloxacin-d8 (hydrochloride) (Synonyms: Hoe-280-d8 hydrochloride) |
| رقم الكتالوجGC48565 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ofloxacin-d8 is intended for use as an internal standard for the quantification of ofloxacin by GC- or LC-MS. Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase.1,2 It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.
1.Sato, K., Matsuura, Y., Inoue, M., et al.In vitro and in vivo activity of DL-8280, a new oxazine derivativeAntimicrob. Agents and Chemother.22(4)548-553(1982) 2.Smith, J.T.The mode of action of 4-quinolones and possible mechanisms of resistanceJ. Antimicrob. Chemother.18 (Suppl. D)21-29(1986)
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