16-Epiestriol (Synonyms: 16-epi Estriol, 16-EpiE3, 16β-hydroxy-17α-Estradiol, NSC 26646) |
| رقم الكتالوجGC49068 |
16-Epiestriol هو مستقلب لإسترون الاستروجين الداخلي مع تأثيرات مضادة للجراثيم ومضادة للالتهابات
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Cas No.: 547-81-9
Sample solution is provided at 25 µL, 10mM.
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16-Epiestriol is a metabolite of the endogenous estrogen estrone .1 It is formed from estrone via a 16β-hydroxy estrone intermediate by reduction of the C-17 ketone. 16-Epiestriol (200 µg/ml) inhibits the growth of carbapenem-resistant A. baumannii.2 It inhibits carrageenan-induced paw edema in rats when administered at a dose of 20 mg/kg.3 Unlike hydrocortisone, 16-epiestriol (240 µg/animal) does not increase plasma or liver glucose levels in adrenalectomized rats.
1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Skariyachan, S., Muddebihalkar, A.G., Badrinath, V., et al.Natural epiestriol-16 act as potential lead molecule against prospective molecular targets of multidrug resistant Acinetobacter baumannii-Insight from in silico modelling and in vitro investigationsInfect. Genet. Evol.82104314(2020) 3.Latman, N.S., Kishore, V., and Bruot, B.C.16-Epiestriol: An anti-inflammatory steroid without glycogenic activityJ. Pharm. Sci.83(6)874-877(1994)
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