Hydroxy Celecoxib |
| رقم الكتالوجGC49130 |
An inactive metabolite of celecoxib
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170571-00-3
Sample solution is provided at 25 µL, 10mM.
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Hydroxy celecoxib is an inactive metabolite of celecoxib .1 It is formed from celecoxib by the cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.2
1.Penning, T.D., Talley, J.J., Bertenshaw, S.R., et al.Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)J. Med. Chem.40(9)1347-1365(1997) 2.Siu, Y.A., Hao, M.-H., Dixit, V., et al.Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variantsDrug Metab. Pharmacokinet.33(5)219-227(2018)
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