Mestranol (Synonyms: EE 3-ME, Ethynyl Estradiol 3-methyl ether, NSC 84032, SC-475, Δ-MVE) |
| رقم الكتالوجGC13477 |
Mestranol هو دواء أولي غير نشط ويصبح نشطًا بيولوجيًا عند التحويل إلى ethinyl estradiol (EE)
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Cas No.: 72-33-3
Sample solution is provided at 25 µL, 10mM.
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Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.Target: Estrogen Receptor/ERRMestranol is absorbed very rapidly from the digestive tract and maximum plasma levels are attained in 1-4 hours, the majority at 1-2 hours. Detectable levels of mestranol are present 24 hours postingestion in 58% of subjects after a 50 μg dose and in 79% after a 100 μg dose. At all dose levels, highest plasma mestranol levels and area under the curve of plasma levels (AUC) occurred in Sri Lankan women, and lowest plasma levels in Nigerian women, even when corrected for body surface differences [1].
References:
[1]. Goldzieher, J.W., T.S. Dozier, and A. de la Pena, Plasma levels and pharmacokinetics of ethynyl estrogens in various populations: II. Mestranol. Contraception, 1980. 21(1): p. 17-27.
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