U 93631 |
| رقم الكتالوجGC11013 |
U 93631 عبارة عن ليجند لمستقبل GABAA لهيكل كيميائي جديد مع IC 50 من 100 نانومتر ، وقد ثبت أنه يسبب تحللًا سريعًا يعتمد على الوقت لتيارات الكلور في الخلية الكاملة المستحثة بـ GABA في مستقبلات GABAA المؤتلفة.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 152273-12-6
Sample solution is provided at 25 µL, 10mM.
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U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. target: GABAA receptorIC 50: GABAA receptor[1]In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,rather than acting as an open channel blocker. [1]
References:
[1]. Dillon,GH et al.U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.Molecular Pharmacology October 1993, 44 (4) 860-865
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