DprE1-IN2 |
| رقم الكتالوجGC18263 |
DprE1-IN2 (المركب 18) هو مثبط قوي لـ DprE1 مع IC50 من 28 نانومتر.
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Cas No.: 1615713-87-5
Sample solution is provided at 25 µL, 10mM.
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DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect[1].
DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice[1].
References:
[1]. Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37.
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