R1487 Hydrochloride |
| رقم الكتالوجGC19304 |
R1487 هيدروكلوريد هو مثبط قوي للغاية وانتقائي p38α ، بقيم Kd تبلغ 0.2 نانومتر و 29 نانومتر لـ p38α و p38β ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 449808-64-4
Sample solution is provided at 25 µL, 10mM.
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R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.target: p38α;R1487 (Hydrochloride) potently inhibits cytokine production in a variety of in vitro and in vivo models.[1]R1487 (Hydrochloride) inhibits production of TNFR by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS.[1]
References:
[1]. Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.
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