ChX710 |
| رقم الكتالوجGC34329 |
يمكن لـ ChX710 أن يهيئ استجابة الانترفيرون من النوع الأول للحمض النووي الخلوي ، والذي يحفز تسلسل محفز ISRE ، والجينات الخلوية المحفزة للإنترفيرون (ISG) ، وفسفرة عامل تنظيم الإنترفيرون (IRF) 3
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Cas No.: 2438721-44-7
Sample solution is provided at 25 µL, 10mM.
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ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
ChX710 treatment is found to efficiently prime the cellular response to DNA transfection via STING as assessed by strong synergistic effects on IFN-β expression at both transcriptional and protein levels [1].
[1]. Khiar S, et al. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017 May 31;7(1):2561.
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