CCK-B Receptor Antagonist 2 |
| رقم الكتالوجGC38746 |
CCK-B Receptor Antagonist 2 ، المركب 15b ، هو مضاد فعال وفعال عن طريق الفم لـ Gastrin / CCK-B بقيمة IC50 تبلغ 0.43 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 155412-88-7
Sample solution is provided at 25 µL, 10mM.
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CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].
CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1].
[1]. Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41.
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