CCP peptide TFA |
| رقم الكتالوجGC38748 |
ببتيد CCP TFA هو ببتيد حلقي اصطناعي (CCP) ويستخدم كركيزة للكشف عن الأجسام المضادة لـ CCP من الناحية المصلية
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2].
CCP peptide is used as a new antigenic substrate in anti-CCP ELISA to detect anti-citrullinated protein antibodies (ACPAs). The anti-CCP ELISA is extremely specific (98%), with a reasonable sensitivity (68%). The anti-CCP ELISA is very useful for diagnostic and therapeutic strategies in rheumatoid arthritis (RA)[3].
[1]. Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94. [2]. SÖderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8. [3]. Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.
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