Cercosporin (Synonyms: CGP 049090, NSC 153111) |
رقم الكتالوجGC18521 |
يتم إنتاج Cercosporin عن طريق أحد مسببات الأمراض النباتية ، Cercosporakikuchii ، وأصباغ إلسينوكروم ، وهي أصباغ من عائلة الفطريات إلسينويCercosporin هو محسس ضوئي قوي ذو طول موجي تنشيط قصير ، ومناسب في الغالب للعلاجات الضوئية السطحية (PDT) ، خاصة عندما يكون من الضروري تجنب الثقوب. يحتوي Cercosporin على السمات الهيكلية للبيريلكوينون اللازمة لنشاط PKC مع IC50 من 0.6-1.3 ميكرومتر
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Cas No.: 35082-49-6
Sample solution is provided at 25 µL, 10mM.
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1].Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].
Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1].Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1].
References:
[1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396.
[2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25.
Cas No. | 35082-49-6 | SDF | |
المرادفات | CGP 049090, NSC 153111 | ||
Chemical Name | (13bR)-6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione | ||
Canonical SMILES | COC(C1=O)=C(CC(O)C)C2=C3C(C(C(C=C4OCO5)=O)=C(O)C(OC)=C3CC(C)O)=C4C6=C5C=C(O)C1=C26 | ||
Formula | C29H26O10 | M.Wt | 534.5 |
الذوبان | DMF: soluble,DMSO: soluble,Ethanol: soluble | Storage | Store at -20°C,protect from light |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.8709 mL | 9.3545 mL | 18.7091 mL |
5 mM | 0.3742 mL | 1.8709 mL | 3.7418 mL |
10 mM | 0.1871 mL | 0.9355 mL | 1.8709 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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Quality Control & SDS
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- Purity: >95.00%
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