Cerestat (Synonyms: CNS 1102) |
| رقم الكتالوجGC50060 |
Cerestat (Cerestat) هو أحد مضادات مستقبلات NMDA غير التنافسية مع تأثير وقائي للأعصاب.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137160-11-3
Sample solution is provided at 25 µL, 10mM.
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Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID:8295213 |Schäbitz et al (2000) The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID:10884477
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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