Claficapavir (Synonyms: A1752) |
| رقم الكتالوجGC66467 |
Claficapavir (A1752) هو مثبط محدد لبروتين نوكليوكابسيد (NC) مع IC50 حوالي 1 μ ؛ M. يربط Claficapavir بقوة HIV-1 NC (Kd = 20 نانومتر) وبالتالي يمنع خصائص المرافقة لـ NC ويؤدي إلى نشاط مضاد للفيروسات جيد ضد HIV-1.
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Cas No.: 2055732-24-4
Sample solution is provided at 25 µL, 10mM.
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Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].
Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].
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