CP-409092 |
| رقم الكتالوجGC31052 |
CP-409092 هو ناهض جزئي لمستقبلات GABAA ، مع نشاط مضاد للقلق
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 194098-25-4
Sample solution is provided at 25 µL, 10mM.
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CP-409092 is a GABA(A) partial agonist, used for the treatment of anxiety.
The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [14C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats[1].
[1]. Kamel A, et al. Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats. Xenobiotica. 2010 Jun;40(6):400-14.
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