Cytostatin |
| رقم الكتالوجGC43360 |
سيتوستاتين هو مثبط قوي وانتقائي لـ PP2A مع نشاط واعد مضاد للأورامCytostatin هو أيضا مثبط لالتصاق الخلية بالمصفوفة خارج الخلية ويحفز موت الخلايا المبرمجينتمي Cytostatin إلى عائلة fostriecin من المنتجات الطبيعية
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Cas No.: 682329-63-1
Sample solution is provided at 25 µL, 10mM.
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Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
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