Danicamtiv (Synonyms: MYK-491, SAR440181) |
| رقم الكتالوجGC60120 |
Danicamtiv (MYK-491) ، عامل مؤثر في التقلص العضلي ، هو منشط خيفي انتقائي للميوسين القلبييزيد Danicamtiv وظيفة القلب الانقباضية ويحافظ على الكفاءة الميكانيكية
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Cas No.: 1970972-74-7
Sample solution is provided at 25 µL, 10mM.
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Danicamtiv, an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].
[1]. Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707 [2]. Johan Oslob, et al. 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm). WO2016118774A1.
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