الصفحة الرئيسية>>Signaling Pathways>> Cell Cycle/Checkpoint>> ROCK>>DJ4

DJ4

رقم الكتالوجGC72959

ويعد DJ4 مثبطًا تنافسيًا لـ RCK1/2 (قيم التركيز النصفي:5 و 50 نانومتر) و MRCKα/β (قيم التركيز النصفي:10 و 100 نانومتر).

Products are for research use only. Not for human use. We do not sell to patients.

DJ4 التركيب الكيميائي

Cas No.: 1681020-24-5

الحجم السعر المخزون الكميّة
5 mg
146٫00
متوفر
10 mg
234٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Description of DJ4

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer.

References:
[1]. Kale VP, et al. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354(2):299-310.

Chemical Properties of DJ4

Cas No. 1681020-24-5 SDF
Formula C19H16N4OS M.Wt 348.42
الذوبان DMSO : 10 mg/mL (28.70 mM; ultrasonic and warming and heat to 60°C) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of DJ4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8701 mL 14.3505 mL 28.701 mL
5 mM 0.574 mL 2.8701 mL 5.7402 mL
10 mM 0.287 mL 1.435 mL 2.8701 mL
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In vivo Formulation Calculator (Clear solution) of DJ4

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for DJ4

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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