الصفحة الرئيسية>>Lipids>> Sphingolipids>>(E)-2-Hexadecenal

(E)-2-Hexadecenal (Synonyms: trans-2-Hexadecenal)

رقم الكتالوجGC41268

Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase.

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(E)-2-Hexadecenal التركيب الكيميائي

Cas No.: 22644-96-8

الحجم السعر المخزون الكميّة
500μg
83٫00
متوفر
1mg
160٫00
متوفر
5mg
672٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (E)-2-Hexadecenal

Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types. It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.

Chemical Properties of (E)-2-Hexadecenal

Cas No. 22644-96-8 SDF
المرادفات trans-2-Hexadecenal
Canonical SMILES O=C([H])/C=C/CCCCCCCCCCCCC
Formula C16H30O M.Wt 238.4
الذوبان DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (E)-2-Hexadecenal

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.1946 mL 20.9732 mL 41.9463 mL
5 mM 0.8389 mL 4.1946 mL 8.3893 mL
10 mM 0.4195 mL 2.0973 mL 4.1946 mL
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In vivo Formulation Calculator (Clear solution) of (E)-2-Hexadecenal

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 23 reference(s) in Google Scholar.)

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