FASN inhibitor 1 |
| رقم الكتالوجGC33398 |
مثبط FASN 1 هو مثبط سينثاز الأحماض الدهنية (FASN) المستخرج من براءة اختراع US20170119786A1 ، المركب 242A.
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Cas No.: 2097262-60-5
Sample solution is provided at 25 µL, 10mM.
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FASN inhibitor 1 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A.
Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN inhibitor 1 (Compound 242A), results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. For monocytes, FASN inhibitor 1 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation[1].
[1]. Buckley, Douglas I, et al. HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS. US20170119786A1
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