Fustin (Synonyms: Dihydrofisetin, NSC 59264) |
رقم الكتالوجGC52047
One-Click Copy Product Info
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Fustinis ((±) -Fustin ؛ 3،7،3 '، 4'-Tetrahydroxyflavanone) هو مثبط قوي للأميلويد β (Aβ)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20725-03-5
Sample solution is provided at 25 µL, 10mM.
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Fustin is a polyketide synthase-derived flavanone that has been found in R. verniciflua and has diverse biological activities.1,2,3,4 It enhances epigallocatechin-3-O-gallate-induced decreases in the viability of U266 multiple myeloma cells when used at concentrations of 5 and 10 µM.2 Fustin (50 and 100 mg/kg) inhibits increases in blood glucose levels, as well as serum total cholesterol, triglyceride, and malondialdehyde (MDA) levels, in a mouse model of diabetes induced by streptozotocin .3 It prevents decreases in contextual- and tone fear conditioning freezing time, indicating a reversal of memory deficits, induced by amyloid-β (1-42) (Aβ42) in mice when administered at a dose of 100 mg/kg.4
1.MarÍn, L., GutiÉrrez-Del-RÍo, I., Villar, C.J., et al.De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activityMicrob. Biotechnol.14(5)2009-2024(2021) 2.Kumazoe, M., Fujimura, Y., Yoshitomi, R., et al.Fustin, a flavanonol, synergically potentiates the anticancer effect of green tea catechin epigallocatechin-3-O-gallate with activation of the eNOS/cGMP axisJ. Agric. Food Chem.70(11)3458-3466(2022) 3.Gilani, S.J., Bin-Jumah, M.N., Al-Abbasi, F.A., et al.Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changesSaudi J. Biol. Sci.28(12)6963-6971(2021) 4.Jin, C.-H., Shin, E.-J., Park, J.-B., et al.Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairmentJ. Neurosci. Res.87(16)3658-3670(2009)
| Cas No. | 20725-03-5 | SDF | |
| المرادفات | Dihydrofisetin, NSC 59264 | ||
| Canonical SMILES | OC(C=CC([C@H]1OC2=CC(O)=CC=C2C([C@@H]1O)=O)=C3)=C3O | ||
| Formula | C15H12O6 | M.Wt | 288.3 |
| الذوبان | Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4686 mL | 17.343 mL | 34.6861 mL |
| 5 mM | 693.7 μL | 3.4686 mL | 6.9372 mL |
| 10 mM | 346.9 μL | 1.7343 mL | 3.4686 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)