G907 |
| رقم الكتالوجGC39569 |
G907 هو مضاد انتقائي لجزيء صغير لناقل كاسيت ربط ATP (ABC) ، MsbA
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Cas No.: 2244035-16-1
Sample solution is provided at 25 µL, 10mM.
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G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity[1].
[1]. Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.
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