BB-Cl-Amidine hydrochloride |
| رقم الكتالوجGC35480 |
هيدروكلوريد BB-Cl-Amidine هو مثبط للبيبتيدلارجينين deminase (PAD)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2436747-41-8
Sample solution is provided at 25 µL, 10mM.
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BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor. PAD[1].
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1]. Animal Model: MRL/lpr mice[1].
[1]. Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206.
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