Emapunil (Synonyms: Emapunil, XBD-173) |
| رقم الكتالوجGC35976 |
Emapunil (AC-5216) ، مركب TSPO النشط والانتقائي (مستقبلات البنزوديازيبين في الميتوكوندريا) ينتج تأثيرات مضادة للقلق ومضادة للاكتئاب في نماذج حيوانية مختلفة
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Cas No.: 226954-04-7
Sample solution is provided at 25 µL, 10mM.
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Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development. XBD173 also exerted antipanic activity in humans and, in contrast to benzodiazepines, did not cause sedation or withdrawal symptoms [1]. The selective TSPO ligand, XBD173 (AC-5216, Emapunil), exerts anxiolytic effects not only in animal models, but also in human volunteers [2].
[1]. Costa B, et al. Translocator protein as a promising target for novel anxiolytics. Curr Top Med Chem. 2012;12(4):270-85. [2]. Rupprecht R, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3. [3]. Qiu ZK, et al. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Sci Rep. 2016 Nov 25;6:37345.
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