Esomeprazole magnesium salt (Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt) |
رقم الكتالوجGC36009 |
ملح المغنيسيوم إيزوميبرازول ((S) - ملح المغنيسيوم أوميبرازول) هو مثبط قوي وفعال لمضخة البروتون عن طريق الفم ويقلل من إفراز الحمض من خلال تثبيط H +، K +- ATPase في الخلايا الجدارية المعدية
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Cas No.: 1198768-91-0
Sample solution is provided at 25 µL, 10mM.
Esomeprazole magnesium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole magnesium salt is a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.
[1]. Sandstrom M, et al. Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clin Ther. 2012 Aug;34(8):1828-38. [2]. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9. [3]. Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, et al. Physical and Chemical Stability of Esomeprazole Sodium Solutions. Ann Pharmacother. September 2008 ,42 ( 9 ):1247-1251. [4]. Esomeprazole
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