LX2761 |
| رقم الكتالوجGC36498 |
LX2761 هو مثبط كيميائي قوي ومستقر ضد ناقل الجلوكوز 1 المعتمد على الصوديوم (SGLT1) و SGLT2 في المختبر مع IC50s من 2.2 نانومتر و 2.7 نانومتر لـ hSGLT1 و hSGLT2 ، لكنه يعرض تثبيط SGLT1 محددًا في الجهاز الهضمي (GI).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1610954-97-6
Sample solution is provided at 25 µL, 10mM.
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LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1]. IC50: 2.2 nM (hSGLT1), 2.7nM (hSGLT2)[1]
[1]. Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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