Trimethoprim 3-oxide (Synonyms: Trimethoprim 3-N-oxide) |
| رقم الكتالوجGC37830 |
ثلاثي ميثوبريم 3-أوكسيد (Trimethoprim 3-N-oxide) هو المستقلب الأساسي لتريميثوبريم
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Cas No.: 27653-67-4
Sample solution is provided at 25 µL, 10mM.
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Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim[1].
Trimethoprim 3-oxide is the primary metabolite of trimethoprim[1].Trimethoprim 3-oxide (3-NO-TMP) is converted from trimethoprim by CYP1A1 and CYP1B1 with highest rates in human liver microsomes (HLMs). The CYP1A inhibitor α-Naphthoflavone inhibits Trimethoprim 3-oxide formation, however, other competitive P450 inhibitors has no obvious inhibition on the formation[1].
[1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80.
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